The toxicity of gallic acid, pyrogallol, tannic acid, and Quercus havardi in the rabbit
Dollahite, J.W.; Pigeon, R.F.; Camp, B.J.
American Journal of Veterinary Research 23: 1264-1267
1962
ISSN/ISBN: 0002-9645 PMID: 14028469 Document Number: 3193
In rabbits, the single oral median lethal dose (LD50) of pyrogallol is 1.6 Gm./kg., gallic acid is 5.0 Gm./kg., and tannic acid is 5.0 Gm./kg. The multiple oral LD50 of pyrogallol is 0.7 Gm./kg. per day, gallic acid is 2.8 Gm./kg. per day, and tannic acid is 3.4 Gm./kg. per day, when administered daily for ten days. Tannic acid was absorbed from the gastrointestinal tract into the blood stream in rabbits, sheep, and goats. In rabbits, it was rapidly detoxified or excreted. In rabbits, the lesions produced by all the polyphenols studied and those produced by Quercus havardi had a marked similarity. However, the lesions produced by tannic acid fed in multiple doses more nearly resembled those produced by Q. havardi. These findings suggest that tannins in shin oak may be involved in its toxicity.
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