Theory for Renal Autoregulation by Feedback at the Juxtaglomerular Apparatus
Guyton, A.C.; Langston, J.B.; Navar, G.
Circulation Research 15 Suppl: 187-97
1964
ISSN/ISBN: 0009-7330 PMID: 14206300 Document Number: 3194
The concept that autoregulation of renal blood flow could result from a feedback mechanism operating from the distal tubule to the afferent arteriole at the juxtaglomerular apparatus has been examined. Several different theoretical types of feedback were found which could possibly cause autoregulation; but thus far, only one of these, control of the afferent arteriole in response to changes in osmolality of the tubular fluid at the macula densa, has fitted with other characteristics of renal function. A mathematical model of nephron dynamics showed that osmotic feedback could cause autoregulation and a number of other well-known attributes of renal function. Two types of experiments in dogs based on predictions from this model confirmed the predictions. It is concluded that osmotic feedback could be the cause of renal autoregulation; but until further evidence is available, other types of feedback, particularly sodium feedback, should continue to be considered as possible stimuli for causing a feedback type of autoregulation.
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