Juxtaglomerular apparatus and interstitial cells of the kidney medulla in glomerulonephritis
Pal'tsev, M.A.; Bespalov, D.A.; Shliapnikov, V.V.; Kutyrina, I.M.; Nikishova, T.A.
Arkhiv Patologii 46(2): 64-70
1984
ISSN/ISBN: 0004-1955 PMID: 6712513 Document Number: 234651
The most pronounced hyperplasia of the juxtaglomerular apparatus (JGA) with the appearance of numerous rhombus-like protogranules in the epithelioid cell cytoplasm is found electronmicroscopically in the mesangioproliferative glomerulonephritis (GM) with hypertension while in the membranous FN the hyperplasia was the least pronounced. Hyperplasia of JGA in the fibroplastic GN was observed in the preserved glomeruli only. Morphometric evaluation in mesangioproliferative GN has shown that there is an inverse relationship between the volume of the interstitium and the renin activity in the blood plasma, the positive correlation between the volume of the interstitium and blood pressure and the negative correlation between the elliptical shape of the granules in the JGA epithelioid cells and the surface of the interstitium. Atrophic changes in the interstitial cells are found.