Characteristics of interstitial cells of the adrenal medulla after stimulation of prostaglandin production by lasix
Salikhov, B.N.; Khamraev, A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 111(1): 46-48
1991
ISSN/ISBN: 0365-9615 PMID: 2054473 Document Number: 380453
The paper presents structural characteristics of interstitial cells after a single or multiple administration of lasix. The single dose stimulated the process of prostaglandins synthesis in the interstitial cells of Kidney papillae. The prolonged administration of lasix led to relative decrease in prostaglandin production if compared with that of a single dose. Besides, there was noted formation of these cells second population, which elaborated the connective tissue proteins and glycosaminoglycans. It was suggested that the prolonged administration of lasix effected the interstitial cells causing inanition of their prostaglandin synthesizing ability and stimulating processes of production of the connective tissue intercellular substances by them.