Stimulation of prostaglandin e production by rat synovium induced by intraarticular injection of measles virus

Caspi, D.; Yaron, M.; Yaron, I.; Baratz, M.; Zor, U.

Journal of Rheumatology 9(6): 944-946

1982


ISSN/ISBN: 0315-162X
PMID: 7161786
Document Number: 194373
Measles virus was injected into the joints of rats. Prostaglandin E in organ cultures of synovial tissue removed from injected joints was evaluated. A 9-fold increase of prostaglandin E concentration was found in cultures of synovial membranes from joints injected with measles virus as compared to controls. Histologic examination revealed inflammation in the synovial membranes of joints injected with virus. We suggest that prostaglandin E may mediate joint inflammation induced by measles virus.

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