Stimulation of prostaglandin e production by rat synovium induced by intraarticular injection of measles virus
Caspi, D.; Yaron, M.; Yaron, I.; Baratz, M.; Zor, U.
Journal of Rheumatology 9(6): 944-946
1982
ISSN/ISBN: 0315-162X PMID: 7161786 Document Number: 194373
Measles virus was injected into the joints of rats. Prostaglandin E in organ cultures of synovial tissue removed from injected joints was evaluated. A 9-fold increase of prostaglandin E concentration was found in cultures of synovial membranes from joints injected with measles virus as compared to controls. Histologic examination revealed inflammation in the synovial membranes of joints injected with virus. We suggest that prostaglandin E may mediate joint inflammation induced by measles virus.