A comparison of the effect of flurbiprofen on prostaglandin synthetase from human rheumatoid synovium and enzymatically active animal tissues
Crook, D.; Collins, A.J.; Rose, A.J.
Journal of Pharmacy and Pharmacology 28(6): 535
1976
ISSN/ISBN: 0022-3573 PMID: 7661 Document Number: 108715
Flurbiprofen inhibited 3 different prostaglandin [PG] synthetase preparations [human, bovine, rabbit] in a dose-related manner, as did aspirin and indomethacin. The variation observed in the relative molar potencies of the drugs between the 3 different PG synthetase preparations is in accord with the concept of synthetase isoenzymes in different tissues. While flurbiprofen was 300 times more active than aspirin and equipotent with indomethacin in the rabbit renal medulla preparation, it was 2760 and 5600 times more potent than aspirin on bovine seminal vesicle microsomes and human rheumatoid synovial microsomes, respectively.sbd.about 3 and 20 times more potent than indomethacin.