Effect of cotrimoxazole (Bactrim) on cholesterol metabolism
Pugalendi, K.V.; Ramakrishnan, S.; Padmanabhan, P.
Indian Journal of Biochemistry and Biophysics 33(2): 141-144
1996
ISSN/ISBN: 0301-1208 PMID: 8754625 Document Number: 455238
Male albino rats when treated with antimicrobial cotrimoxazole (trimethoprim+sulphamethaoxazole) showed an elevation of plasma high density lipoprotein (HDL) cholesterol and lecithin cholesterol acyl transferase activity (LCAT). Very low density lipoprotein and low density lipoprotein (VLDL+S4, 5LDL) cholesterol levels were decreased. However, total blood cholesterol and aortic cholesterol levels were normal. There was decreased synthesis of cholesterol and its content in the liver. Intestinal cholesterol mobilisation (studied using [U-14C]glucose) towards lymph was normal in spite of decreased synthesis by intestines. Decreased fecal excretion of bile acids and neutral sterols and normal intestinal contribution may be mainly involved in the blood cholesterol homeostasis.