Effect of cholesterol oxidase on lipid metabolism in experimental atherosclerosis
Suvorova, I.M.; Titov, A.V.; Il'in, G.I.; Kostin, E.D.; Poltavchenko, G.M.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1986(5): 8-9
1986
ISSN/ISBN: 0031-2991 PMID: 3467301 Document Number: 270843
The effect of microbial cholesteroloxidase (derived from Streptomyces sp.) on lipid metabolism in rabbits with experimental atherosclerosis was studied. Intravenous infusion of cholesterol oxidase for 4-5 weeks led to a reduction of the blood plasma lipid and cholesterol levels and regression of the atherosclerotic changes in the aorta. The obtained data indicate that cholesterol oxidase possesses a very active and specific antiatherogenic effect.