Lipoprotein receptors, cholesterol metabolism, and atherosclerosis
Goldstein, J.L.; Brown, M.S.
Archives of Pathology 99(4): 181-184
1975
ISSN/ISBN: 0363-0153 PMID: 163632 Document Number: 85545
Deposition of cholesterol esters in the arterial intima is a characteristic feature of human atherosclerosis. Little is known about the mechanisms by which cells normally regulate their cholesterol ester content. Recent studies in cultured human cells demonstrate the existence of a cell surface receptor that binds plasma low-density lipoproteins and regulates the sterol content of cells by modulating the rates of uptake, esterification and synthesis of cholesterol. A possible role for this lipoprotein receptor in the pathogenesis of atherosclerosis is discussed.