How does endogenous and exogenous cholesterol influence the lipoprotein metabolism. Effects of long-term endurance exercise, and accumulation of cholesterol ester on the aortic wall
Terao, T.; Miyoshi, M.; Yoshioka, T.; Nakano, S.
Nihon Seirigaku Zasshi. Journal of the Physiological Society of Japan 47(3): 130-140
1985
ISSN/ISBN: 0031-9341 PMID: 4032319 Document Number: 249221
We first supplied the rats with sucrose which accelerates the synthesis of the very low density lipoprotein (VLDL). After 5 weeks ingestion, we investigated the effects of the long-term endurance exercise on the concentration of the endogenous cholesterol and on the accumulation of the cholesterol ester on the arterial wall, with the emphasis on lipid metabolism, especially on lipoprotein metabolism. The concentrations of triglyceride and VLDL in sucrose-ingested group were significantly higher than control. As to the aortic wall, the total amount of cholesterol ester was increased (almost twice). Regular endurance exercise over long period after serum and hepatic lipids had already reached a high level did not reduced the triglyceride in the liver but in serum. It showed be emphasized that the exercise reduces triglyceride and VLDL-cholesterol, and to this extent does contribute to alleviation of hyperlipidemia and to prevention or moderation of arteriosclerosis.