Effect of dietary Lactobacillus casei on cholesterol metabolism in apoE-deficient mice
Tang, Z.; Zhu, H.; Xia, M.; Hou, M.
Wei Sheng Yan Jiu 38(4): 406-408
2009
ISSN/ISBN: 1000-8020 PMID: 19689067 Document Number: 635724
To explore the effect of dietary Lactobacillus casei on cholesterol metabolism in apoE-deficient mice in order to find the possible active components of Lactobacillus casei in anti-atherogenesis. ApoE-deficient mice were randomly divided into 4 groups: control group (A), Lactobacillus casei 10(8) cfu/ml group (B), Lactobacillus casei 10(10) cfu/ml group (C), Lactobacillus casei 10(12) cfu/ml group (D). ApoE-deficient mice were administrated with dietary contenting Lactobacillus casei for 16 weeks and the cholesterol levels of serum, liver, aorta in different groups were determined by enzymatic method. When compared with control group, total cholesterol accumulation in aortas and livers showed a significant reduction in dietary mice fed with contenting Lactobacillus casei (P < 0.05). At the same time, it had higher HDL-C level compared to control group. This result suggested that Lactobacillus casei could have the capacity of improvement.