Effect of benzisoselenazolones and organic diselenides on graft versus host reaction and immunoglobulins levels in chickens
Błaszczyk, B.; Inglot, A.D.; Toivanen, P.; Młochowski, J.; Szymaniec, S.
Archivum Immunologiae et Therapiae Experimentalis 43(5-6): 299-303
1995
ISSN/ISBN: 0004-069X PMID: 8744650 Document Number: 447466
Two week old chickens were treated once daily for 5 days with AE8 - 1-pyridyl-1,2-benzisoselenazol-3(2H)-one, AE22 - bis-2-(N-phenyle-carboxamido) 1 pyridyl diselenide and AE31 - bis(phenylo-diselenide with R-3 = CONHC-18H-37). Their whole blood alone or blood mixed with thymus cells were used to generate graft versus host (GvH) reaction in 15 day old chicken embryos. The treatment of the chickens with the compounds stimulated the GvH reaction modifying activity of the donor cells as measured by increase of the spleen weight of the recipient chicken embryos. On the other hand, treatment with these compounds inhibited the IgG or IgM production in chickens immunized with human albumin.