Carcinogenic effects of cytostatic protocols in CBA/Ca mice
Ember, I.; Raposa, T.; Varga, C.; Herceg, L.; Kiss, I.
In Vivo 9(1): 65-69
1995
ISSN/ISBN: 0258-851X PMID: 7545447 Document Number: 445259
An in vivo mouse model was developed in order to study the characteristics of secondary tumor induction by cytostatic drug combinations used in human anticancer treatment. In this model we have proved the carcino-leukemogenic effects of widely used chemotherapeutical drug combinations (CHOP, COPP, COPBLAM, VAM). The carcinogenic hazards of cyclophosphamide and other alkylating drugs could also be demonstrated in our model.
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