Effect of different cytostatic protocols on oncogene expression in CBA/Ca mice
Ember, I.; Raposa, T.; Varga, C.; Kiss, I.
Anticancer Research 15(4): 1285-1288
1995
ISSN/ISBN: 0250-7005 PMID: 7654010 Document Number: 454896
In vivo investigations on oncogene action may provide new findings on the toxicology of potential carcinogens. In this study we investigated the early effects of different cytostatic protocols on early oncogene expression in CBA/Ca mice. Most of the examined protocols showed detectable early changes, especially those containing cyclophosphamide. The most frequently involved oncogenes were N-ras, c-myc, and c-myb.