Correlations between gross and microscopic lesions in carcinogenic studies in mice
Frith, C.H.; Boothe, A.D.; Greenman, D.L.; Farmer, J.H.
Journal of Environmental Pathology and Toxicology 3(3 Spec No): 139-153
1980
ISSN/ISBN: 0146-4779 PMID: 6988540 Document Number: 154984
Microscopic diagnoses of a number of spontaneous and induced neoplasms in mice were correlated with the gross findings of the EDO1 [effective dose producing a 1% tumor rate] and a number of other carcinogenic studies conducted at NCTR [National Center for Toxicological Research, USA] to determine the value of detailed histopathologic examinations in bioassay testing. For organs such as thymus, lung, adrenal, Harderian gland and urinary bladder, 50% or more of the neoplastic lesions would be missed if at least 1 histological section were not examined from each organ. For organs such as the liver and mammary gland, a single tissue section did not greatly improve the ability to detect neoplastic lesions beyond that afforded by a thorough necropsy examination.