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Carcinogenic alkylating substances. I. Dimethylsulfate, carcinogenic action in rats and probable cause of occupational cancer

Druckrey, H.; Preussmann, R.; Nashed, N.; Ivankovic, S.

Zeitschrift für Krebsforschung 68(1): 103-111

1966

ISSN/ISBN: 0301-1585
PMID: 4228031
Document Number: 3122
In systematic studies with alkylating substances, dimethylsulphate (DMS) has been investigated for carcinogenic activity in rats. Subcutaneous injections of 16 and 8 mg DMS/kg respectively, given once a week, produced local sarcomas in 12 out of 18 surviving rats, in some with metastases to the lungs, and in one a carcinoma of the liver. The mean survival time was 300 and 500 days respectively. Hence, DMS is considered as a direct acting carcinogen. A bronchiogenic carcinoma, which caused the death of a 47 year old worker in a chemical industry, is reported and related to exposure to DMS vapours, 11 years before. Its acceptance as occupational cancer is confirmed. In the interest of active cancer prevention, a dose cooperation between industries and experimental carcinogenesis research is recommended.

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Carcinogenic alkylating substances. I. Dimethylsulfate, carcinogenic action in rats and probable cause of occupational cancer

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