In vitro topically applied fluoroquinolone penetration into the anterior chamber
Fukuda, M.; Sasaki, K.
Nippon Ganka Gakkai Zasshi 99(5): 532-536
1995
ISSN/ISBN: 0029-0203 PMID: 7785510 Document Number: 443264
The penetration mode of five fluoroquinolone ophthalmic solutions (OFLX, NFLX, LVFX, LFLX and CPFX) through the rabbit cornea was examined with an in vitro experimental system. The system was an artificial anterior eye segment model made of acrylamide covered with a New Zealand albino rabbit cornea with a scleral flap. In vivo studies on the penetration of OFLX and NFLX ophthalmic solutions into the anterior chamber of albino rabbits were performed separately. Parameters gained from in vivo pharmacokinetic analysis and those from the model eye were compared. The permeability coefficients (K) (cm/s) through the cornea and partition coefficient were 6.95 times 10-7 cm/s in LVFX, 6.78 times 10-7 cm/s in OFLX, 3.58 times 10-7 cm/s in LFLX, 2.46 times 10-6 cm/s in CPFX and 0.06 times 10-7 cm/s in NFLX, and 0.24, 0.23, 0.14, 0.06 and 0.07, respectively. High correlation was seen between the corneal permeability coefficients, and the partition coefficient Cmax of OFLX obtained from the in vivo study was higher than that of NFLX. The applied experimental system would be a useful tool for the estimation of the in vivo Cmax of the examined drug.