The influence of urea on the penetration kinetics of topically applied corticosteroids
Wohlrab, W.
Acta Dermato-Venereologica 64(3): 233-238
1984
ISSN/ISBN: 0001-5555 PMID: 6204485 Document Number: 221642
The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the active constituent. (b) A given therapeutic effect could be obtained with a reduced concentration of the active ingredient.