cDNA sequences of Schistosoma japonicum coding for two cathepsin B-like proteins and Sj32
Merckelbach, A.; Hasse, S.; Dell, R.; Eschlbeck, A.; Ruppel, A.
Tropical Medicine and Parasitology Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit 45(3): 193-198
1994
ISSN/ISBN: 0177-2392 PMID: 7899786 Document Number: 435307
Sequences of three cDNAs of Schistosoma japonicum are presented. Two of them code for the antigens Sj32 (hemoglobinase) and cathepsin B. The third clone represents a mutant derivative of the cathepsin B gene. The DNA and amino acid sequences are compared to their homologues from S. mansoni The mutant cathepsin B, in which the Cys-29 in the active center is replaced by Ser, is discussed with respect to a possible function.