Effect of methylmercury chloride on brain muscarinic receptor in rat
Zhang, Z.; Wu, D.
Hua Xi Yi Ke Da Xue Xue Bao 25(4): 388-392
1994
ISSN/ISBN: 0257-7712 PMID: 7744379 Document Number: 433807
In this study, we found that methylmercury chloride inhibited the binding of 3H-QNB to muscarinic receptor of rat brain tissue in vitro with IC-50 values of 0.0137 +- 0.0037mol/L. It also decreased the densities of muscarinic receptor and affinity to 3H-QNB. In vivo test system, the rats were exposed to methylmercury chloride (ip) 0, 1.5, 2.5, 3.5 mg/kg cntdot d on the 7-12th day of gestation. On the 7, 14 and 21th day after birth, the offsprings were killed, and the cerebrum and cerebellum were immediately dissected on ice and homogenizated. The ligand assays were carried out. The result showed the effect of inhibition on the binding to cerebrum and cerebellum with significant correlation.