Prophylactic effect of oral terbinafine on the development of infection in guinea pigs inoculated with Trichophyton mentagrophytes
Uchida, K.; Yamaguchi, H.
Japanese Journal of Antibiotics 47(1): 50-56
1994
ISSN/ISBN: 0368-2781 PMID: 8114273 Document Number: 429055
Prophylactic effect was studies of a novel oral antifungal agent terbinafine (TBF) on the development of local infection in guinea pigs after inoculation of Trichophyton mentagrophytes. TBF was administered orally in a single dose of 6.25 or 12.5 mg/kg, 8, 24, 48 or 72 hrs before the inoculation, and the drug effect was assessed on the basis of local symptoms and culture study. The result of experiments demonstrated that oral TBF more or less prevented the development of the derinatophytic infection, depending on the dosage and the timing of administration, the complete prevention was achieved in the animals that were administered with 12.5 mg/kg of TBF 24 hrs prior to the inoculation of T. mentagrophytes. This suggests a good transferability and intracutaneous retaining of orally administered TBF.