Congenital factor V deficiency and intraventricular hemorrhage of prenatal origin
Bonvini, G.; Cotta-Ramusino, A.; Ricciardi, G.
La Pediatria Medica e Chirurgica Medical and Surgical Pediatrics 16(1): 93-94
1994
ISSN/ISBN: 0391-5387 PMID: 8029101 Document Number: 428720
The Authors describe a case of congenital coagulation factor V deficiency with severe prenatal intraventricular hemorrhage. Factor V is an essential enzyme catalysing the process of thrombin generation. Low levels of enzyme were also found in both parents, who demonstrate subclinic alterations of coagulation parameters. The severe deficiency of factor V in the newborn (8%) caused frequent and severe intracranial and gastric hemorrhages that brought newborn to death in few weeks.