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Critical evaluation of fibronectin in pregnancy-induced hypertension/pre-eclampsia and placental insufficiency

Lehnen, H.; el Magd, M.; Schöngen, R.N.; Reinecke, T.

Zentralblatt für Gynakologie 116(6): 352-357

1994

ISSN/ISBN: 0044-4197
PMID: 8048291
Document Number: 424064
1. Fibronectin does not correlate with the grade of proteinuria. 2. Fibronectin does not correlate with birth weight. 3. Fibronectin level is not elevated in pregnancy-induced hypertension and preeclampsia. 4. Fibronectin level is elevated in cases of preeclampsia, combined with chronic placental insufficiency respectively intrauterine growth retardation. 5. There is a statistic significant difference between pregnancy-induced hypertension/preeclampsia with or with out placental insufficiency. 6. Extremely problematic pregnancies ended in all pregnancies with values of fibronectin above 0.4 g/l in caesarean section without knowledge of the elevated fibronectin level at the time of operation. 7. In the group of pregnancy-induced hypertension the fibronectin level is elevated in relation to control group. This increase is particularly evident, if a placental insufficiency is concontinant with preeclampsia.

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