Uterine and placental vascular lesions in pregnancy induced hypertension and its relationship to pregnancy outcome

Yin, L.; Han, J.; Ma, H.

Zhonghua Fu Chan Ke Za Zhi 33(8): 459-461

1998


ISSN/ISBN: 0529-567X
PMID: 10806741
Document Number: 495388
To study the vascular lesions of the uterus and placenta in severe pregnancy induced hypertension (SPIH) and its relationship to pregnancy outcomes. 29 cases of SPIH and 29 cases of normal term pregnancies (NTP) were examined to observe the expressions of IgA, IgG, IgM and C3 in the vascular walls of placental villus and uterus placental bed by immunohistochemical technique. (1) In SPIH, the positive expression rates of the IgA, IgG, IgM and C3 in the vascular wall of placental villus (20.1%, 24.1%, 72.4%, and 65.5%) and uterus placental bed (20.0%, 20.0%, 70.0% and 60.0%) were significantly higher than those of NTP (all P < 0.05), while there were no expression in NTP. (2) The thickening of endangium angiostenosis, fibronoid necrosis and acute arterial atherosis were found at the sites of positive expressions in SPIH. (3) In SPIH complicated by intrauterine growth retardation (IUGR), the positive expressions of the immunocomplex and complement in the vessel walls (76.2%) were significantly higher than those of the SPIH without IUGR (50%, all P < 0.05). In SPIH, there are depositions of immunocomplex and complement on the vessel walls of placental villus and uteroplacenta. Immunological factor plays an important role in the development of PIH.

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