Changes and significance of concentrations of serum vascular endothelial growth factor in patients with pregnancy induced hypertension
Chen, J.; Wen, A.; Hong, D.
Zhonghua Fu Chan Ke Za Zhi 35(2): 72-74
2000
ISSN/ISBN: 0529-567X PMID: 11809101 Document Number: 525271
To detect the changes of concentrations of serum vascular endothelial growth factor (VEGF) in patients with pregnancy induced hypertension (PIN) as well as to explore the relationship between VEGF and pathogenesis of PIN. Serum VEGF concentrations in 23 healthy nonpregnant women (nonpregnant group), 30 normal pregnant women (normal pregnancy group) and 37 women with PIH (PIH group) were measured by sandwich enzyme-linked immunoadsorbent assay (ELISA). Serum concentrations of VEGF were significantly higher in normal pregnancy group (149.39 +/- 27.15) ng/L than those in nonpregnant group (11.98 +/- 3.99) ng/L (P < 0.001), peaking in the second trimester of pregnancy (183.84 +/- 49.02) ng/L and decreasing in the third trimester (118.37 +/- 34.29) ng/L. Serum VEGF concentrations (64.45 +/- 24.33) in PIH group were significantly lower than those in normal late pregnancy group (118.37 +/- 34.29) ng/L (P < 0.01). There was a trend that serum VEGF concentrations in PIH group decreased with the severity of PIH (P < 0.05). The decrease of VEGF may play and important role in the pathogenic mechanism of PIH.