Elevated serum vascular endothelial growth factor levels in patients with polycythemia vera and thrombotic complications
Cacciola, R.R.; Di Francesco, E.; Giustolisi, R.; Cacciola, E.
Haematologica 87(7): 774-775
2002
ISSN/ISBN: 0390-6078 PMID: 12091131 Document Number: 548113
Vascular endothelial growth factor (VEGF) induces platelet activation in a thrombin-dependent manner. We tested the serum VEGF levels in patients with polycythemia vera (PV) and found a significant correlation between increased VEGF and thrombosis. These findings suggest that high VEGF levels might contribute to the occurrence of thrombosis in this hematologic malignancy.
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