Pregnancy induced hypertension in crossbred rats maternal and fetal outcome of pregnancy
Hutten, J.W.M.; Kuijpers, J.C.; Van Velzen, D.; Wallenburg, H.C.S.
International Journal of Feto-Maternal Medicine 1(1): 51-56
1988
Document Number: 199237
Because of the possible influence of fetomaternal imcompatibility on the occurrence of pregnancy-induced hypertensive disease and the outcome of pregnancy, a comparative study was performed on 25 Wistar female rats bred with Wister males, 33 Wistar females bred with Brown Norway males, and 12 Wistar females bred with Brown Norway males treated with the antiplatelet drug ticlopidine. Thirteen non-pregnant Wistar females were used as controls. Blood pressure near term was reduced in all pregnant animals as compared with non-pregnancy controls, but the decrease on blood pressure was less pronounced in crossbred pregnancies. Maternal weight and uterine arterial 6-keto-PGF1.alpha. production were lower in cross-bred than in non-crossbred animals, and proteinuria was found to be increased. In the crossbred ticlopidine group, 6-keto-PGF1.alpha. production was in the same range as that in non-pregnant animals, and blood pressure and proteinuria were comparable with those in the non-crossbred group. It is concluded that fetomaternal incompatibility in this model increases the susceptibility of developing a pregnancy-induced hypertensive disorder.