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Effect of hormonally-induced prolongation of pregnancy in rabbits on maternal and fetal serum lipids

Ockert, C.; Willgerodt, H.; Keller, E.; Senger, H.; Pludra, R.

Zentralblatt für Gynakologie 107(12): 744-751

1985

ISSN/ISBN: 0044-4197
PMID: 2412367
Document Number: 252405
The alterations of the lipid metabolism produced by placental insufficiency were investigated in animal experiments. Pregnant rabbits received Chlormadinon-acetate by intramuscular injection. The pregnancy was prolongated for 4 days, and a placental insufficiency developed. The lipid metabolism of the mothers and the fetuses was investigated by determination of beta-lipoproteides, triglycerides, cholesterol and HDL- and LDL/VLDL-cholesterol. The most important result is an increase of the concentrations of triglycerides and cholesterol of the fetuses during prolongation of pregnancy. Of the different cholesterol fractions estimated the LDL/VLDL-cholesterol-ratio excellently reflects the changes of the lipid metabolism during prolonged pregnancy.

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