N-methyl-3H]methylphenazepam--a new ligand for benzodiazepine receptors
Golovko, A.I.; Sofronov, G.A.; Kliuntina, T.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 115(4): 382-383
1993
ISSN/ISBN: 0365-9615 PMID: 8049399 Document Number: 421850
The binding of [N-methyl-3H] methylphenazepam with synaptosomal membranes of rat striatum was studied. The affinity of binding sites to this ligand was higher when compared with [3H] diazepam. No changes in maximal binding capacity were found in two groups. GABA and muscimol increased the binding of [3H] diazepam and had no effect on binding of [N-methyl-3H] methylphenazepam. Diazepam and phenazepam competitively decreased the [N-methyl-3H] methylphenazepam binding. The inhibitor activity of phenazepam was higher.