Peripheral benzodiazepine receptors and their possible biological role
Alexander, B.E.; Klotz, U.
Die Pharmazie 48(8): 563-570
1993
ISSN/ISBN: 0031-7144 PMID: 8105494 Document Number: 412777
While specific BZD receptors in the central nervous system were identified using [3H]diazepam as radioligand, additional binding sites have been found also in peripheral tissues. These so-called "peripheral-type benzodiazepine receptors" occur ubiquitous in various tissues. Different actions on biological processes have been described to be connected with peripheral-type benzodiazepine receptors, but their definite physiological role has not yet been clarified. this review covers basic findings of this second binding site for benzodiazepines, trying to present a survey about those binding sites and their putative biological role.