Hypotension, mental disorders and changes in catecholamine excretion observed during the administration of disulfiram in a case of pheochromocytoma
Serrano, P.A.; Hava-Kuri, I.; Chávez-Lara, B.; Cervantes-Osorio, L.; Zaldivar, H.M.
Archivos del Instituto de Cardiologia de Mexico 48(2): 437-443
1978
ISSN/ISBN: 0020-3785 PMID: 666450 Document Number: 4217
A case of pheocromocytoma treated with disulfiram during ten days in described. Hypotensive and psychiatric effects were observed, which disappeared upon discontinuation of the drug. Urinary amines decreased while the drug was used, and upon interruption of its administration dopamine increased, as a rebound phenomena probably due to availability of tissue dopamine previously blocked by DBH inhibition. The effect of simultaneous administration of alpha-methyldopa is considered.
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