Treatment of idiopathic infertility with testosterone undecanoate. A double blind study
Gregoriou, O.; Papadias, C.; Gargaropoulos, A.; Konidaris, S.; Kontogeorgi, Z.; Kalampokas, E.
Clinical and Experimental Obstetrics and Gynecology 20(1): 9-12
1993
ISSN/ISBN: 0390-6663 PMID: 8462190 Document Number: 416591
This study refert to 50 couples treated for subfertility. Twenty five of these patients were treated with TU (Testosterone Ur econoate), the remaining 25 received placebo. Sperm characteristics, including ejaculate volume, pH, sperm density, morphology, motility, total testosterone, FSH, LH, DHT and E-2 were evaluated both before and after treatment. A statistically significant increase of DHT levels was noticed after TU administration, whereas a marginally significant improvement of sperm morphology was present. Serum FSH concentrations, decreased significantly in the TU group whereas serum LH presented a slight but not statistically significant decrease; 4 pregnancies were achieved by the TU group whereas none were achieved by the patients belonging to the placebo group. The administration of TU per os to patients with idiopathic oligospermia presents a demonstrably positive effect.