Non-cholinergic effects of organophosphates
Bajgar, J.
Casopis Lekaru Ceskych 132(17): 513-517
1993
ISSN/ISBN: 0008-7335 PMID: 8402819 Document Number: 415735
The author summarizes contemporary knowledge on the action of organophosphates with emphasis on non-cholinergic mechanisms. Intoxication with these substances is characterized by four basic processes: absorption, transport, metabolism and the toxic effect proper. The latter involves cholinesterase inhibition at the cholinergic synapses with subsequent accumulation of acetylcholine. However, non-cholinergic processes are also involved such as the effect on levels of cyclic nucleotides, the peptidergic system, receptors, liver metabolism and the stressogenic action. From the review ensues that knowledge of non-cholinergic, mechanisms of action could reveal new approaches to treatment of intoxications with these substances.