Organophosphates--a pediatric hazard
Mayer, B.W.; Schlackman, N.
American Family Physician 11(5): 121-124
1975
ISSN/ISBN: 0002-838X PMID: 1130247 Document Number: 94605
These agents act as anticholinesterases. Signs of toxicity are: overactivity of the parasympathetic nervous system, nausea, vomiting, diarrhea, sweating, abdominal cramps and copious secretions. Large doses may cause sustained depolarization of the motor end plate, leading to muscular paralysis. Death may ensue from respiratory failure. The extensive and often careless use of insecticides, fungicides and pesticides makes organophosphates a particular pediatric hazard. Atropine and pralidoxime chloride are effective for therapy.