Influence of 1,3-di-o-tolylguanidine and rimcazole, selective sigma ligands, on apomorphine and neuroleptic effects
Maj, J.; Rogóz, Z.; Skuza, G.
Polish Journal of Pharmacology 45(3): 327-330
1993
ISSN/ISBN: 1230-6002 PMID: 8106091 Document Number: 408409
1,3-di-o-tolylguanidine and rimcazole act as typical neuroleptics (antagonize the apomorphine-induced aggression and climbing) and at the same time, as dopamine stimulants (antagonize neuroleptic-induced catalepsy). When given alone, they exhibit no visible behavioral effects.
Document emailed within 1 workday
Related Documents
Monnet, F.P.; Debonnel, G.; de Montigny, C. 1992: In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands Journal of Pharmacology and Experimental Therapeutics 261(1): 123-130Massamiri, T.; Duckles, S.P. 1990: Multiple vascular effects of sigma and PCP ligands: inhibition of amine uptake and contractile responses Journal of Pharmacology and Experimental Therapeutics 253(1): 124-129
Leysen, J.E. 1980: 3H-Apomorphine receptors in various rat brain regions: a study of specific and nonspecific binding and the influence of chronic neuroleptic treatment Advances in Biochemical Psychopharmacology 24: 123-132
Bourrie, B.; Bribes, E.; Derocq, J.-M.; Vidal, H.; Casellas, P. 2004: Sigma receptor ligands: applications in inflammation and oncology Current Opinion in Investigational Drugs 5(11): 1158-1163
Klein, M.; Zhou, G.Z.; Paturzo, J.J.; Musacchio, J. 1990: The effect of sigma ligands on dextromethorphan binding sites in the guinea pig Progress in Clinical and Biological Research 328: 129-132
Kvaratskheliia, E.B.; Dabrundashvili, N.G.; Maĭsuradze, E.B.; Kadzhaia, L.N.; Mikeladze, D.G. 2005: The action of dextrorphan and sigma ligands on the spontaneous secretion of interleukins by jurkat cell line Georgian Medical News 127: 74-76
Zharkovskiĭ, A.M.; Allikmets, L.K.; Nurk, A.M. 1982: Influence of the intracaudate administration of kainic acid on the effects of the prolonged use of haloperidol and apomorphine on rats Farmakologiia i Toksikologiia 45(1): 10-12
Massamiri, T.; Duckles, S.P. 1991: Interactions of sigma and phencyclidine receptor ligands with the norepinephrine uptake carrier in both rat brain and rat tail artery Journal of Pharmacology and Experimental Therapeutics 256(2): 519-524
Niemegeers, C.J. 1974: The predictive value of the anti-apomorphine test in dogs for neuroleptic therapy in man Activitas Nervosa Superior 16(1): 56-58
Markovska, V.; Georgiev, V.; Ankov, V. 1979: Influence of x-ray irradiation on the effects of apomorphine and L-dopa with respect to the dopamine level in rat brain and corpus striatum Acta Physiologica et Pharmacologica Bulgarica 5(4): 27-34
Wallach, M.B.; Hedley, L.R.; Peterson, K.E.; Schulz, C.H. 1980: Antagonism of apomorphine induced climbing: is it a valid model for neuroleptic activity? Proceedings of the Western Pharmacology Society 23: 93-98
Nechipurenko, I.D. 1984: Cooperation effects in binding of large ligands to DNA. II. Contact interactions between adsorbed ligands Molekuliarnaia Biologiia 18(4): 1066-1080
Skuza, G. 2000: Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats Polish Journal of Pharmacology 52(4): 313-316
Lishmanov, I.B.; Maslov, L.N.; Krylatov, A.V.; Ugdyzhekova, D.S.; Gilligan, P.; Tam, S.W. 2000: The anti-arrhythmia and pro-arrhythmia properties of sigma-receptor ligands Eksperimental'naia i Klinicheskaia Farmakologiia 63(2): 39-43
Janssen, P.A.; Niemegeers, C.J.; Schellekens, K.H. 1965: Is it Possible to Predict the Clinical Effects of Neuroleptic Drugs (Major Tranquillizers) from Animal Data?i. "neuroleptic Activity Spectra" for Rats Arzneimittel-Forschung 15: 104-117
Steinfels, G.F.; Alberici, G.P.; Tam, S.W.; Cook, L. 1988: Biochemical, behavioral, and electrophysiologic actions of the selective sigma receptor ligand (+)-pentazocine Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 1(4): 321-327
Maslov, L.N.; Krylatov, A.V.; Lishmanov, I.B. 1997: The anti-arrhythmic effect of the selective sigma-receptor antagonist DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'-oxoethyl)piper idine HBr Eksperimental'naia i Klinicheskaia Farmakologiia 60(2): 24-26
Nevalainen, T. 2014: Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands Current Medicinal Chemistry 21(2): 187-203
Vohora, D. 2004: Histamine-selective H3 receptor ligands and cognitive functions: an overview Idrugs: the Investigational Drugs Journal 7(7): 667-673
Gue, M.; Junien, J.L.; Del Rio, C.; Bueno, L. 1992: Neuropeptide y and sigma ligand (JO 1784) suppress stress-induced colonic motor disturbances in rats through sigma and cholecystokinin receptors Journal of Pharmacology and Experimental Therapeutics 261(3): 850-855