Hydroxyurea and lower leg ulcers
Nguyen, T.V.; Margolis, D.J.
Cutis 52(4): 217-219
1993
ISSN/ISBN: 0011-4162 PMID: 8261806 Document Number: 408310
We report four cases of cutaneous lower leg ulcers associated with hydroxyurea treatment for myeloproliferative disorders. This association has been reported in one other series of patients who had chronic myelogenous leukemia and were treated with hydroxyurea. A review of the literature and survey of possible pathogenetic mechanisms is presented.