Painful oral ulcers with hydroxyurea therapy
Norhaya, M.R.; Cheong, S.K.; Ainoon, O.; Hamidah, N.H.
Singapore Medical Journal 38(7): 283-284
1997
ISSN/ISBN: 0037-5675 PMID: 9339092 Document Number: 479981
Five patients treated with hydroxyurea for various haematological malignancies developed multiple painful oral ulcers. Their neutrophil counts were either normal or elevated. The ulcers disappeared with cessation of hydroxyurea. Oral ulcers recurred when hydroxyurea was resumed in one of the patients. As the patients were unable to tolerate this painful side effect, hydroxyurea had to be discontinued. Appearance of painful oral ulceration seems to be independent of dosing rate or total cumulative dose of hydroxyurea.