Synthesis and A1-adenosine receptors affinities of purino[7,8-c]quinazoline-8,10 (9H,11H) -diones as rigid analogues of 8-arylxanthines
Ceccarelli, S.; D'Alessandro, A.; Magnante, F.; Scuri, R.; Zanarella, S.
Farmaco 48(9): 1301-1312
1993
ISSN/ISBN: 0014-827X PMID: 8259987 Document Number: 408311
Title compounds were prepared by a cyclocondensation reaction between 8-(2-aminophenyl)xanthines and trialkyl orthoesters. Some of them showed activities as A1-adenosine receptor antagonists with binding values in the micromolar range. Results are discussed with reference to 1,3-dialkyl-8-arylxanthines. Considerations on the role played by both electronic and conformational factors are also reported.
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