Synthesis and pharmacological evaluation of some 3-phenacyl-5-benzylidene-thiazolidine-2,4-diones
de Lima, J.G.; Perrissin, M.; Chantegrel, J.; Luu-Duc, C.; Rousseau, A.; Narcisse, G.
Arzneimittel-Forschung 44(7): 831-834
1994
ISSN/ISBN: 0004-4172 PMID: 7945517 Document Number: 425074
The synthesis of 54 3-phenacyl-5-benzylidene-thiazolidine-2,4-diones is reported. Eight of them were tested for anti-oedema, analgesic and anticonvulsant activity. Only one compound showed significant anti-oedematous and analgesic, activity. Three compounds protected against tonic seizures and death.
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