Effects of m-nisoldipine on transmembrane currents of guinea pig papillary muscles
An, R.H.; Fan, Z.Z.; He, R.R.
Zhongguo Yao Li Xue Bao 13(4): 341-344
1992
ISSN/ISBN: 0253-9756 PMID: 1456056 Document Number: 403938
Effects of m-Nis on the transmembrane currents were studied using single sucrose gap voltage clamp technique. The amplitude of slow inward current (I(si)) was 10.6 +/- 4.1 microA. Maximal inward current was induced at a membrane potential range between -20 to -25 mV. The amplitude of I(si) were significantly decreased by m-Nis (0.2 mumol.L-1) with a reduction of 47.3%. The transient inward current (I(ti)) induced by ouabain was also greatly depressed or prevented by m-Nis, resulting in the inhibition of DAD.