Effects of m-nisoldipine and nisoldipine on isolated uterine muscle
Li, F.F.; Fu, S.X.; Li, Y.S.
Zhongguo Yao Li Xue Bao 13(1): 59-62
1992
ISSN/ISBN: 0253-9756 PMID: 1605036 Document Number: 404991
m-Nisoldipine (m-Nis) and nisoldipine (Nis) inhibited spontaneous contraction of isolated non-pregnant human myometrium, IC50 being 3.7 .+-. 0.7 .mu.mol .cntdot. L-1 for m-Nis and 6.0 .+-. 0.9 .mu.mol .cntdot. L-1 for Nis. Both drugs also suppressed spontaneous and oxytocin-induced contraction of isolated pregnant rat uterus. In isolated uterus from virgin rat, both drugs inhibited the contractions induced by KCl, acetylcholine (Ach), and oxytocin (Oxy), the values of pD'2 against KCl, ACh, Oxy being 9.0 .+-. 0.2, 6.1 .+-. 0.1, and 5.9 .+-. 0.1 for m-Nis and 9.1 .+-. 0.3, 5.7 .+-. 0.2, and 5.6 .+-. 0.1 for Nis respectively. The results indicate that both m-Nis and Nis may be clinically useful for the treatment of dysmenorrhea and premature labour.