Effects of nisoldipine in coronary artery disease: a radioisotopic approach

Tartagni, F.; Melandri, G.; De Tommaso, I.; Fallani, F.; di Niro, M.; Antonioli, P.; Dondi, M.; Corbelli, C.; Magnani, B.

Journal of Cardiovascular Pharmacology 20(Suppl 5): S65-S67

1992


ISSN/ISBN: 0160-2446
PMID: 1282617
Document Number: 394698
The clinical, electrocardiographic, and scintigraphic effects of oral administration of nisoldipine were investigated using two separate study protocols. In the first, the acute effects of nisoldipine were evaluated by means of nuclear ventricolography and demonstrated no deleterious effects on global contractility and an amelioration of several hypokinetic segments. In the second protocol, myocardial perfusion effects were evaluated by means of tomoscintigraphy. An improvement of segmental uptake of thallium was caused by nisoldipine. The addition of atenolol markedly reduced the rate-pressure product and further improved myocardial perfusion.

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