C-reactive Protein Associated with Coronary Artery Disease in Iranian Patients with Angiographically Defined Coronary Artery Disease
Seyyed Mohammad Reza Kazemi-Bajestani; Ghayour, M.-Mobarhan; Ebrahimi, M.; Moohebati, M.; Habib-Esmaeili, A.; Gordon A. A. Ferns
Clinical Laboratory 53(1-2): 49-56
2007
ISSN/ISBN: 1433-6510 PMID: 17323825 Document Number: 8404
Introduction: Several cross-sectional and cohort studies have reported an association between serum markers of inflammation such as C-reactive protein, and coronary heart disease in Caucasian populations. We aimed to in- vestigate the relationship between levels of serum C-reactive protein (hs-CRP) and the presence of coronary artery disease (CAD) in Iranian patients undergoing coronary angiography. Methods: Serum hs-CRP, fasting lipid profile and blood glucose levels were measured in 110 patients (61 males and 49 females) undergoing routine coronary angiography. Anthropometric features including blood pressure were determined using standard procedures. Demographic characteristics, including post-menopausal status and smoking habit were assessed by questionnaire. Results: Of the 110 subjects undergoing angiography, 74 (67.28%) had significant CAD (CAD+) and 36 (32.72%) were classified as having insignificant CAD (CAD-). Mean age (p Conclusion: Serum hs-CRP is an independent predictor of angiographically defined CAD in an Iranian population. Measurement of the serum hs-CRP level may improve risk stratification among patients suspected of having CAD. The strong correlations between serum hs-CRP with LDL and smoking may be due to the putative pro-inflammatory effects of these two parameters. The association with serum triglycerides may be indirect and related to insulin resistance and adiposity.
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