Electrophysiologic effects of total flavones of Hippophae rhamnoides L on guinea pig papillary muscles and cultured rat myocardial cells
Wu, J.; Yu, X.J.; Ma, X.; Li, X.G.; Liu, D.
Zhongguo Yao Li Xue Bao 15(4): 341-343
1994
ISSN/ISBN: 0253-9756 PMID: 7801778 Document Number: 432843
The effects of total flavones of Hippophae rhamnoides L (TFH) were evaluated using conventional microelectrode technic. After administration of TFH 100 - 200 mg cntdot L-1, the action potential duration of 50% repolarization, (APD-50) was shortened both in cultured rat myocardial cells and in guinea pig papillary muscles. The slope of phase 4 of depolarization (SP-4) in cultured rat myocardial cells was decreased and the contractile force (CF) in guinea pig papillary muscles was weakened. Arrhythmias evoked by strophantin G in guinea pig papillary muscles were suppressed by TFH 100 mg cntdot L-1. These findings suggested that the influence of TFH on myocardial cells may be resulted mainly from its inhibition of Ca-2+ influx and its interference with intracellular Ca-2+ reservoir.