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In vitro effects of cyclopiazonic acid mycotoxin on turkey papillary muscles

Miller, C.D.; Richard, J.L.; Hembrough, F.B.; Osweiler, G.D.; Cox, D.F.

American Journal of Veterinary Research 51(5): 836-838

1990

ISSN/ISBN: 0002-9645
PMID: 2337289
Document Number: 354837
An in vitro bioassay system was used to study the effects of cyclopiazonic acid (CPA) mycotoxin on cardiac muscle. Acute exposure to 6 micrograms of CPA/ml of modified Krebs-Henseleit solution significantly (P less than 0.05) decreased 5 in vitro turkey cardiac muscle performance criteria: maximal weight a muscle could lift; maximal contraction velocity; relaxation velocity; time to peak contraction; and total time for muscle contraction and relaxation. The effect on these 5 criteria appeared to result from intracellular changes partially associated with calcium availability and were irreversible, suggesting that physiologic changes had developed after acute exposure to CPA.

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