Iontophoretic permeation of sodium cromoglycate through synthetic membrane and excised hairless mouse skin
Li, L.C.; Vu, N.T.; Allen, L.V.
Journal of Pharmacy and Pharmacology 44(5): 444-446
1992
ISSN/ISBN: 0022-3573 PMID: 1359063 Document Number: 401217
The iontrophoretic transport properties of sodium cromoglycate were characterized using a synthetic membrane and excised hairless mouse skin. The permeation rate of sodium cromoglycate through the synthetic membrane was found to be linearly dependent on the density of electrical current applied. Passive diffusion through the excised hairless mouse skin was not demonstrated for sodium cromoglycate; however, under iontophoresis, an appreciable permeation was exhibited by the drug through the animal skin, which was also found to be a function of the electrical current density.