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In-vitro permeation of some beta-blockers across the hairless mouse skin

Ghosh, T.K.; Chiao, C.S.; Gokhale, R.D.

Journal of Pharmacy and Pharmacology 45(3): 218-219

1993

ISSN/ISBN: 0022-3573
PMID: 8097781
Document Number: 408685
To support the development of a suitable transdermal dosage form for beta-blockers, in-vitro, skin permeation studies of nine beta-blockers were conducted at 37 degree C across the excised abdominal skin of hairless mouse mounted on the receptor compartment of a two-chambered Valia-Chien glass diffusion cell. The drugs varied in lipophilicity, whereas pK-a values were comparable. Permeability coefficients were calculated from the steady-state flux values. Agreement was found between the permeability coefficient and the drug lipophilicity, expressed as the octanol-buffer distribution coefficient.

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