Drug permeation through synthetic lipid membranes. Part 13: the effects of tensides on the permeation of ionized drugs
Fürst, W.; Neubert, R.; Förster, B.; Reppel, L.
Die Pharmazie 34(5-6): 315-316
1980
ISSN/ISBN: 0031-7144 PMID: 7413708 Document Number: 162383
The permeation of substances present in the ionized form is most markedly affected by tensides containing ions of opposite sign. These tensides produce a considerable increase in permeation. The effect of micelle formation will become evident only if the transport of the free drug through the membrane is more rapid than the release of the drug from the micelles. If the concentrations of nonionic tensides are less than the critical micelle concentration, a permeation increase occurs which is presumably caused by a reduction of the surface tension of the membrane.