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The dynamics of the drug release from ointment bases. Part 5: the effects of tensides on the liberation of atropine from eye ointments

Pasich, J.; Bether, W.; Malaga, M.

Die Pharmazie 36(4): 267-269

1981

ISSN/ISBN: 0031-7144
PMID: 7255527
Document Number: 181782
The liberation of atropine sulphate from 12 eye ointments added with lipophil emulsifiers (cholesterol and glycerol monostearate) and propylene glycol was determined in vitro in the apparatus of Olszewski and Kubis, using the reaction of atropine with bromothymol blue for spectrometric estimation. The best release was observed with vaseline added with propylene glycol. In contrast, glycerol monostearate and cholesterol produced no considerable increase in liberation. Glycerol monostearate exerted the greatest effect on the liberation of atropine sulphate from the base described in the Polish Pharmacopoeia IV. Glycerol monostearate was the most suited emulsifier for a paraffin-lanolin-water base. The maximum of release is delayed by the addition of the emulsifier to the ointment base.

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