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Disorders of bone marrow hematopoiesis long time after the action of cytostatic preparations

Bogdashin, I.V.; Sycheva, E.V.; Zhdanov, V.V.; Afanas'eva, O.N.; Zapuskalova, O.P.; Novitskiĭ, V.V.; Gol'dberg, E.D.

Biulleten' Eksperimental'noi Biologii i Meditsiny 113(3): 283-284

1992

ISSN/ISBN: 0365-9615
PMID: 1421227
Document Number: 400643
We studied the condition of CBA mice bone marrow hemopoiesis and functional activity of adherent cells 6 months after a single treatment with vinblastine (VB), doxorubicin (DR) and cyclophosphamide (CP) in LD10 dose (6, 22 and 250 mg/kg, respectively). There was a long-term disorganization of bone marrow cell composition. The damage may be attributed to exhaustion of the pools of stem cells and changes in function of the cells formed by hemopoiesis induction microenvironment.

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